Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Systemic exposure following topical administration of acyclovir is minimal. Dermal carcinogenicity studies were not conducted.
Results from the studies of carcinogenesis, mutagenesis and fertility are not included in the full prescribing information for ZOVIRAX Cream due to the minimal exposures of acyclovir that result from dermal application. Acyclovir cream should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Animal Data Acyclovir was not teratogenic in the mouse, rabbit, or rat at exposures greatly in excess of human exposure. Nursing Mothers It is not known whether topically applied acyclovir is excreted in breast milk.
Systemic exposure following topical administration is minimal. However, after oral administration of ZOVIRAX, acyclovir concentrations have been documented in breast milk in two women and ranged from 0. These concentrations would potentially expose the nursing infant to a dose of acyclovir up to 0. Nursing mothers who have active herpetic lesions near or on the breast should avoid nursing.
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© Copyright 2017 ZOVIRAX 50 mg/g CREMA , 1 tubo de 2 g. Precio: €. USO CUTÁNEO..