Sildenafil 50mg 100mg - For Consumers

The side effects are quite mild and disappear within a few hours of using the medication. Some of the most common side effects of Sildenafil Citrate pills are headaches, nose stuffiness, dizziness, indigestions and rashes. Avoid drinking any alcoholic beverages as this could cause severe side-effects. Depending on the dosage you take the medication in, the side effects may be more severe than mild.

Before using Sildenafil Citrate, you should consult with your medical physician to ensure that you are taking it in the right dosage. Its safety under these circumstances has not been studied yet. Most medications have some kind of side effects associated with them. The commonest of these side effects are temporary and mild and fade away without any special attention. These include warmth or redness in your face, neck, or chest; stuffy nose; headache; upset stomach; or back pain.

However, in some cases, these mild side effects may persist or become bothersome. In such cases, seek medical attention. Also, in some rare cases, it may lead to severe side effects like sudden vision loss; ringing in your ears, or sudden hearing loss; chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; irregular heartbeat; swelling in your hands, ankles, or feet; shortness of breath; vision changes; feeling light-headed, fainting; or penis erection that is painful or lasts 4 hours or longer.

Seek medical attention if you notice any of these side effects. Side effects that are not listed here may also occur. People older than 65 years might be prescribed a lower dosage since they are more prone to suffer from side effects. Taking too much Viagra increases your risk of side effects. It could cause you to suffer from low blood pressure and faint.

It also increases your risk of a condition called priapism , which can cause permanent damage to your penis. If you believe that you have accidentally taken too much Viagra, you should visit your local emergency department immediately. Can I combine Viagra with other erectile dysfunction drugs? Taking more than one medication for ED will not increase the effects and will put you at risk of serious side effects.

This is consistent with ritonavir's marked effects on a broad range of P substrates. Although the interaction between other protease inhibitors and sildenafil has not been studied, their concomitant use is expected to increase sildenafil levels. In a study of healthy male volunteers, co-administration of sildenafil at steady state 80 mg t.

Concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma levels of sildenafil. In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin mg daily for 3 days on the systemic exposure of sildenafil or its major circulating metabolite.

Pharmacokinetic data from patients in clinical trials showed no effect on sildenafil pharmacokinetics of CYP2C9 inhibitors such as tolbutamide, warfarin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, ACE inhibitors, and calcium channel blockers.

These effects on the metabolite are not expected to be of clinical consequence. In Vivo Studies No significant interactions were shown with tolbutamide mg or warfarin 40 mg , both of which are metabolized by CYP2C9. In a study of healthy male volunteers, sildenafil mg did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction 80 mg t.

Clinical Studies In clinical studies, VIAGRA was assessed for its effect on the ability of men with erectile dysfunction ED to engage in sexual activity and in many cases specifically on the ability to achieve and maintain an erection sufficient for satisfactory sexual activity. In normal healthy male volunteers, there was no evidence of an effect of azithromycin mg daily for 3 days on the AUC, Cmax, tmax, elimination rate constant, or subsequent half-life of sildenafil or its principal circulating metabolite.

Grapefruit juice is a weak inhibitor of CYP3A4 gut wall metabolism and may give rise to modest increases in plasma levels of sildenafil. Although specific interaction studies were not conducted for all medicinal products, population pharmacokinetic analysis showed no effect of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors such as tolbutamide, warfarin, phenytoin , CYP2D6 inhibitors such as selective serotonin reuptake inhibitors, tricyclic antidepressants , thiazide and related diuretics, loop and potassium sparing diuretics, angiotensin converting enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP metabolism such as rifampicin, barbiturates.

In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, an inducer of CYP3A4 [moderate], CYP2C9 and possibly of CYP2C19 at steady state mg twice a day with sildenafil at steady state 80 mg three times a day resulted in Therefore, concomitant administration of strong CYP3A4 inducers, such as rifampin, is expected to cause greater decreases in plasma concentrations of sildenafil.

Nicorandil is a hybrid of potassium channel activator and nitrate. Due to the nitrate component it has the potential to result in a serious interaction with sildenafil.

There are no data on the interaction of sildenafil and non-specific phosphodiesterase inhibitors such as theophylline or dipyridamole. Preclinical studies showed additive systemic blood pressure lowering effect when PDE5 inhibitors were combined with riociguat. In clinical studies, riociguat has been shown to augment the hypotensive effects of PDE5 inhibitors. There was no evidence of favourable clinical effect of the combination in the population studied.

Concomitant use of riociguat with PDE5 inhibitors, including sildenafil, is contraindicated see section 4. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in a few susceptible individuals.

This is most likely to occur within 4 hours post sildenafil dosing see sections 4. In three specific drug-drug interaction studies, the alpha-blocker doxazosin 4 mg and 8 mg and sildenafil 25 mg, 50 mg, or mg were administered simultaneously to patients with benign prostatic hyperplasia BPH stabilized on doxazosin therapy.

When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. These reports included dizziness and light-headedness, but not syncope.

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