Although beta-adrenergic receptor blockade is useful in the treatment of angina , hypertension , and heart failure there are situations in which sympathetic stimulation is vital. In patients with severely damaged hearts, adequate ventricular function may depend on sympathetic drive. In the presence of AV block, beta-blockade may prevent the necessary facilitating effect of sympathetic activity on conduction. Beta2-adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm and may also interfere with exogenous bronchodilators in such patients.
Pharmacokinetics Adults In man, absorption of metoprolol is rapid and complete. Plasma levels achieved are highly variable after oral administration.
When administered orally, it exhibits stereoselective metabolism that is dependent on oxidation phenotype. Elimination is mainly by biotransformation in the liver, and the plasma half-life ranges from approximately 3 to 7 hours. The systemic availability and half-life of metoprolol in patients with renal failure do not differ to a clinically significant degree from those in normal subjects.
Consequently, no reduction in metoprolol succinate dosage is usually needed in patients with chronic renal failure. Overdose If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call Otherwise, call a poison control center right away.
US residents can call their local poison control center at Canada residents can call a provincial poison control center. Symptoms of overdose may include: Notes Do not share this medication with others. Talk with your doctor about lifestyle changes that may help this medication work better such as stress reduction programs, exercise , and dietary changes. Have your blood pressure and pulse heart rate checked regularly while taking this medication.
Learn how to check your own blood pressure and pulse at home, and share the results with your doctor. Consult your doctor for more details. Missed Dose If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Storage Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.
You may report side effects to Health Canada at Before taking metoprolol, tell your doctor or pharmacist if you are allergic to it; or to other beta-blockers such as atenolol, propranolol ; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: Other symptoms of low blood sugar, such as dizziness and sweating, are unaffected by this drug.
This product may also make it harder to control your blood sugar. Check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. This drug may make you dizzy or drowsy. Alcohol or marijuana can make you more dizzy or drowsy.
Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Talk to your doctor if you are using marijuana. During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. Discuss the risks and benefits with your doctor. This drug passes into breast milk.
Take only as directed by your doctor. Maximum dosage for Toprol XL should not exceed mg daily unless otherwise directed by your doctor. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.
Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medication or medical condition. What are the questions to ask your doctor before taking Metoprolol?
Is it possible for me to take Metoprolol with other drugs? Should certain beverages, foods and other products be avoided when I take Metoprolol? What are the possible drug interactions of Metoprolol? How will Metoprolol work in my body?
The dosage is based on your medical condition and response to treatment. What is Toprol XL Prescribed price Do not crush or chew extended-release tablets. They may price blood pressure and cause disturbing side-effects. Copyright c First Databank, price of toprol, Inc. Is it possible for me to take Metoprolol with other drugs? Note The health and toprol information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. Drug interactions may change how your medications work or increase your risk for serious side effects, price of toprol. The relationship between toprol metoprolol levels and reduction in exercise heart rate is independent of the pharmaceutical formulation. What toprol the questions to ask your doctor before taking Metoprolol? Patients were stabilized on optimal concomitant therapy for heart failure, including diuretics, ACE inhibitorscardiac glycosides, and nitrates. For the treatment of price blood pressureit may take several weeks before you get the full benefit of this drug. Information last revised May
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