Doxazosin 4mg tab

Most people with high blood pressure do not feel sick. You should see a benefit from this drug within 1 to 2 weeks. Tell your doctor if your condition does not improve or if it worsens for example, your blood pressure readings remain high or increase, or your BPH symptoms worsen. Dizziness, lightheadedness , drowsiness, unusual tiredness , or weight gain may occur.

If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: Get medical help right away if you have any very serious side effects, including: Rarely, males may have a painful or prolonged erection lasting 4 or more hours. If this occurs, stop using this drug and get medical help right away, or permanent problems could occur. A very serious allergic reaction to this drug is rare.

However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at If you don't take it at all: Your symptoms may not improve or they may get worse over time. If you stop taking it suddenly: If your condition improved while taking the medication regularly and you stop taking doxazosin suddenly, your symptoms may come back.

If you don't take it on schedule: You may not see a full benefit of this medication. If you double up your dose or take it too close to your next scheduled time, you may be at higher risk of experiencing serious side effects. What to do if you miss a dose: If you miss a dose, take it as soon as you can. Never try to catch up by taking two doses at once. This could result in toxic side effects How to tell if the drug is working: You may be able to tell this drug is working for benign prostatic hyperplasia BPH if you have an easier time urinating and experience fewer symptoms of obstruction and irritation.

Important considerations Important considerations for taking doxazosin Keep these considerations in mind if your doctor prescribes doxazosin oral tablet for you. General Take the extended-release tablet with breakfast.

Take the extended-release tablet in the morning. You can cut or crush the immediate-release tablet. If dizziness, lightheadedness, or palpitations are bothersome they should be reported to the physician, so that dose adjustment can be considered. Patients should also be told that drowsiness or somnolence can occur with doxazosin mesylate or any selective alpha1 adrenoceptor antagonist, requiring caution in people who must drive or operate heavy machinery.

Patients should be advised about the possibility of priapism as a result of treatment with alpha1 antagonists. Patients should know that this adverse event is very rare. If they experience priapism, it should be brought to immediate medical attention for, if not treated promptly, it can lead to permanent erectile dysfunction impotence.

Both doxazosin mesylate, an alpha1 inhibitor, and finasteride, a 5-alpha reductase inhibitor, are highly protein bound and hepatically metabolized. There is no definitive controlled clinical experience on the concomitant use of alpha1 inhibitors and 5-alpha reductase inhibitors at this time. A search through a data base of hypertensive patients and BPH patients revealed 4 hypertensives in which drug-related neutropenia could not be ruled out and one BPH patient in which drug related leukopenia could not be ruled out.

Two hypertensives had a single low value on the last day of treatment. In cases where follow-up was available the WBCs and neutrophil counts returned to normal after discontinuation of doxazosin mesylate.

No patients became symptomatic as a result of the low WBC or neutrophil counts. In vitro data in human plasma indicate that doxazosin mesylate has no effect on protein binding of digoxin, warfarin, phenytoin or indomethacin.

There is no information on the effect of other highly plasma protein bound drugs on doxazosin mesylate binding. Doxazosin mesylate has been administered without any evidence of an adverse drug interaction to patients receiving thiazide diuretics, beta-blocking agents, and nonsteroidal anti-inflammatory drugs.

The clinical significance of this increase in doxazosin mesylate AUC is unknown. In clinical trials, doxazosin mesylate tablets have been administered to patients on a variety of concomitant medications; while no formal interaction studies have been conducted, no interactions were observed.

Doxazosin mesylate tablets have been used with the following drugs or drug classes: There is no evidence that similar lesions occur in humans. Mutagenicity studies revealed no drug- or metabolite-related effects at either chromosomal or subchromosomal levels. This effect was reversible within two weeks of drug withdrawal. There have been no reports of any effects of doxazosin mesylate on male fertility in humans.

There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, doxazosin mesylate should be used during pregnancy only if clearly needed. Radioactivity was found to cross the placenta following oral administration of labelled doxazosin mesylate to pregnant rats. Patients should be advised about the possibility of priapism as a result of treatment with alpha1 antagonists.

Patients should know that this adverse event is very rare. If they experience priapism, it should be brought to immediate medical attention for if not treated promptly, it can lead to permanent erectile dysfunction impotence.

Both doxazosin, an alpha1 inhibitor, and finasteride, a 5-alpha reductase inhibitor, are highly protein bound and hepatically metabolized. There is no definitive controlled clinical experience on the concomitant use of alpha1 inhibitors and 5-alpha reductase inhibitors at this time.

A search through a data base of hypertensive patients and BPH patients revealed 4 hypertensives in which drugrelated neutropenia could not be ruled out and one BPH patient in which drug-related leukopenia could not be ruled out.

Two hypertensives had a single low value on the last day of treatment. In cases where followup was available the WBCs and neutrophil counts returned to normal after discontinuation of doxazosin mesylate. No patients became symptomatic as a result of the low WBC or neutrophil counts.

In vitro data in human plasma indicate that doxazosin mesylate has no effect on protein binding of digoxin, warfarin, phenytoin or indomethacin. There is no information on the effect of other highly plasma protein bound drugs on doxazosin binding. Doxazosin mesylate has been administered without any evidence of an adverse drug interaction to patients receiving thiazide diuretics, beta-blocking agents, and nonsteroidal anti-inflammatory drugs.

The clinical significance of this increase in doxazosin AUC is unknown. In clinical trials, doxazosin mesylate tablets have been administered to patients on a variety of concomitant medications; while no formal interaction studies have been conducted, no interactions were observed. Doxazosin mesylate tablets have been used with the following drugs or drug classes: There is no evidence that similar lesions occur in humans. Mutagenicity studies revealed no drug-or metabolite-related effects at either chromosomal or subchromosomal levels.

This effect was reversible within two weeks of drug withdrawal. There have been no reports of any effects of doxazosin on male fertility in humans. Teratogenic Effects, Pregnancy Category C. There are no adequate and wellcontrolled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, doxazosin mesylate should be used during pregnancy only if clearly needed.

Radioactivity was found to cross the placenta following oral administration of labelled doxazosin to pregnant rats. It is not known whether this drug is excreted in human milk.

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